Toxicity Assessment Alternatives.pdf

Toxicity Assessment Alternatives PDF

Toxicity Assessment Alternatives: Methods, Issues, Opportunities contains a broad array of critical surveys, contributed by active and respected investigators, describing their research and offering updates on toxicity assessment alternatives, directions determined by current and future grant programs, opportunities for mechanistically based test methods to detect endocrine disruptor activity, the use of alternatives in the Department of Defense hazard assessment initiatives, and the issues and opportunities for validation and regulatory acceptance. Several of these advances make use oftransgenic models that reduce the time and cost of carcinogenicity testing. Others use tissue cultures for the assessment of endocrine disrupting chemicals. Cultures of human epidermal keratinocytes are applicable as models for sulfur mustard lesions, and in vitro protein denaturation is used as a chemical test for assessing the ocular and dermal irritation potential of cosmetic prod­ ucts. Molecular modeling is applied to explaining chemical toxicity. Commercially developed assay systems have undergone extensive evaluation by their manufacturers. Some of these await external valida­ tion, and others await acceptance by North American and European regulatory agencies. Toxicity Assessment Alternatives: Methods, Issues, Opportunities provides information from members of the scientific and regulatory communities on what has been achieved and what has been accepted in alternatives to animal testing.

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2.89 MB DATEIGRÖSSE
147576863X ISBN
Englisch SPRACHE
Toxicity Assessment Alternatives.pdf

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Human Toxicity : BRE Group Human toxicity: kg 1,4 dichlorobenzene (1,4-DB) eq. * The emission of some substances (such as heavy metals) can have impacts on human health. Assessments of toxicity are based on tolerable concentrations in air, water, air quality guidelines, tolerable daily …

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Alternative methods for toxicity testing | EU … Alternative methods for toxicity testing In line with Directive 2010/63/EC on the protection of animals used for scientific purposes, sectoral pieces of EU chemicals legislation (e.g. cosmetics, industrial chemicals) that rely on (eco)toxicological information either require or strongly encourage the use of alternatives to animal testing.

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