Purinergic and Pyrimidinergic Signalling II.pdf

Purinergic and Pyrimidinergic Signalling II PDF

Physiological, pharmacological and molecular biological data generated over the past three decades have demonstrated the existence of two major families of extracellular receptors, the P1, a family of four G-protein coupled receptors and the P2, a family of at least 12 receptors responsive to purine (ATP, ADP) and pyrimidine (UTP) nucleotides through which adenosine and ATP can function as extracellular messengers. The present two-part volume represents an integrated compendium of invited chapters by leading researchers in the area focusing on advances in the understanding of purinergic and pyrimidinergic signaling systems, their role(s) in tissue function and pathophysiology and advances in developing potential new medications based on the modulation of P1 and P2 receptor signaling processes. The volumes will thus provide the reader with a topical, comprehensive and integrated overview of this important area.

Purinergic signalling. - Abstract - Europe PMC

3642632238 ISBN
Englisch SPRACHE
Purinergic and Pyrimidinergic Signalling II.pdf


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Sofia Voigt

01.09.2008 · The concept of purinergic signalling arose from experiments designed to find the identity of the non-adrenergic, non-cholinergic (NANC) inhibitory neurotransmitter in the gut.1 However, it has taken many years for the more general importance of the various roles of ATP as a physiological messenger in the gut to be recognised. Later, after the concept of co-transmission was established, ATP Inhibitory neuromuscular transmission mediated …

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Purinergic receptors as future targets for treatment of ... pathophysiological roles of purinergic signalling in the gut, and I believe that the time is ripe for serious exploration of the therapeutic potential of purinergic compounds for a variety of gut disorders. While there are some studies of perinatal development of purinergic signalling in the mammalian gut, I …

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