EBNA1 and Epstein-Barr Virus Associated Tumours.pdf

EBNA1 and Epstein-Barr Virus Associated Tumours PDF

Lori Frappier

This SpringerBrief is comprehensive account of the functions and effects of the Epstein-Barr virus (EBV) EBNA1 protein that relate to EBV-associated cancers and evidence for EBNA1 contributions to these cancers.   EBNA1 was the first EBV protein detected and the most critical for EBV latent infection. EBNA1 fulfills multiple functions at EBV genomes which have been described in many (sometimes confusing) reports over the last 28 years. While these were initially thought to be the only roles of EBNA1, many reports in recent years have shown that EBNA1 also directly affects cellular processes in ways that would be expected to contribute to oncogenesis. However, the degree to which EBNA1 promotes cell survival and oncogenesis in various types of human tumours is not entirely clear and a matter of debate. This book offers a current synopsis of EBNA1 functions in EBV latency, including functions in DNA replication, mitotic segregation and transcription. Mechanisms of these EBNA1 functions is also discussed as well as implications for tumourigenesis. In addition, the cellular effects of EBNA1 will be reviewed, including how EBNA1 manipulates specific cellular proteins and relationships to EBV-associated lymphomas and carcinomas.

22.10.2018 · Despite its critical role in cancer development, no EBV- or EBV latent protein-targeted therapy is available. The EBV-encoded latent protein, Epstein-Barr nuclear antigen 1 (EBNA1), is expressed in all EBV-associated tumors and acts as the only latent protein in some of these tumors. This versatile protein functions in the maintenance EBNA1 and Epstein Barr Virus Associated …

8.58 MB DATEIGRÖSSE
1461468868 ISBN
Englisch SPRACHE
EBNA1 and Epstein-Barr Virus Associated Tumours.pdf

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Sofia Voigt

Frappier L. (2013) EBNA1 Contributions to EBV-Associated Tumours. In: EBNA1 and Epstein-Barr Virus Associated Tumours. SpringerBriefs in Cancer Research, vol 3. Springer, New York, NY In: EBNA1 and Epstein-Barr Virus Associated Tumours.

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Matteo Müller

Download EBNA1 and Epstein-Barr Virus Associated Tumours or any other file from Books category. HTTP download also available at fast speeds.

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Noel Schulze

01.02.2004 · EBV was the first human virus to be directly implicated in carcinogenesis. It infects >90% of the world’s population. Although most humans coexist with the virus without serious sequelae, a small proportion will develop tumors. Normal host populations can have vastly different susceptibility to EBV-related tumors as demonstrated by geographical and immunological variations in the prevalence Is the Epstein–Barr virus EBNA-1 protein an …

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Jason Lehmann

Ebna1 And Epstein Barr Virus Associated …

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Jessica Kohmann

This SpringerBrief will a comprehensive account of the functions and effects of the Epstein-Barr virus (EBV) EBNA1 protein that relate to EBV-associated cancers and evidence for …